The Evidence behind Inhibitor Treatment with Recombinant Factor VIIa

The evidence behind inhibitor treatment with recombinant factor VIIa.

Over the past 10 years considerable use has been made of recombinant factor VIIa (rFVIIa) for the treatment of patients with inhibitors to coagulation factors. During this time, its place in the management of acute bleeds and surgery has become better defined. Although pharmacokinetic studies report the half-life of rFVIIa as 2.7 h, there is considerable intersubject variability. Moreover, rFVI...

The evidence behind inhibitor treatment with porcine factor VIII.

Factor VIII auto- and alloantibodies neutralise porcine factor VIII to a lesser extent than factor VIII of human origin. The reduced reactivity of the porcine molecule, predominantly due to sequence variation in the A2 and C2 domains, has been the rationale for using porcine factor VIII to secure haemostasis for patients with factor VIII inhibitors. Porcine factor VIII has been shown to provide...

Treatment of midgestational placental haemorrhage with recombinant factor VIIa.

Evidence and desperation in off-label prescribing: recombinant factor VIIa.

Off label prescribing—that is, prescribing a medicine for an indication not listed in the product information, or for a patient outside the approved age range—is common, but controversial. On the one hand, it can promote clinical innovation and provide options for patients for whom no other alternatives are available. On the other hand, it can be harmful, because safety data are often lacking; ...

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys.

BACKGROUND Infection with the Ebola virus induces overexpression of the procoagulant tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-factor pathway could ameliorate the effects of Ebola haemorrhagic fever. Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus. METHODS We used a rhesus macaque...